El ibuprofeno cambia el sabor de lo que comes: descubre por qué
The prolonged use of ibuprofen has been associated with the preservation of metabolic function and reducing the risk of metabolic diseases, such as Alzheimer’s, diabetes, and colon cancer. In addition to its anti-inflammatory properties, researchers have discovered that ibuprofen and naproxen also inhibit an important blood sugar receptor.
Ibuprofen inhibits the sweet taste and glucose detection in humans, suggesting an additional mechanism for reducing the risk of metabolic diseases, as highlighted in a study conducted by researchers at the Monell Chemical Senses Center and Rutgers University in New Jersey, USA.
This inhibition of sweet taste seems to be a disadvantage but is actually an advantage for the body, potentially becoming a new way to reduce the risk of metabolic diseases by inhibiting sweet taste throughout the body. Published in the «British Journal of Pharmacology,» the research shows that these medications may have positive effects on glucose metabolism by inhibiting sweet taste receptors (TAS1R2-TAS1R3).
Previous studies have shown that the human sweet taste receptor transmits the perception of sweets in the mouth and can help regulate glucose metabolism throughout the body. Furthermore, ibuprofen and naproxen, both anti-inflammatory drugs, are structurally similar to sweet taste receptor inhibitors and have been linked to metabolic benefits.
«We found that ibuprofen and naproxen inhibit the activation of the sweet taste receptor in humans, as well as in human cells,» said Dr. Paul Breslin, the lead author and a member of Monell, who explains that these medications inhibit sweet taste by blocking the taste response.
In cellular studies, ibuprofen reduced the molecular signaling of sucrose and sucralose in human kidney cells expressing the sweet taste receptor. Additionally, at concentrations reflecting human plasma levels after a typical dose taken at home, ibuprofen inhibited sweet taste and oral glucose detection similar to postprandial blood glucose levels.
In experiments, participants who rinsed their mouths with ibuprofen showed reduced perception of sweetness from various sugars and sweeteners. Other studies have also shown a close link between ibuprofen use and reduced risk of chronic diseases.
The most obvious implication, according to Breslin, is in type 2 diabetes: high blood sugar levels decrease with regular ibuprofen use. The second implication is a decreased risk of diseases affecting glucose metabolism in specific tissues, such as Alzheimer’s and certain types of cancer.
«Our study connects the two functions of TAS1R receptors: sugar intake and subsequent modulators of glucose metabolism,» says Breslin, who is also a nutrition science professor at Rutgers University.
This study demonstrates that ibuprofen not only modulates inflammation but also acts as an inhibitor of TAS1R2-TAS1R3, a receptor found in most tissues and regulatory organs. Previous evidence suggests that inhibiting TAS1R2-TAS1R3 receptors can alter metabolism.
«Our work connects the dots. By considering these inflammatory and metabolic diseases like Alzheimer’s and diabetes, if we manage taste receptors throughout the body, this could be crucial for reducing glucose levels and subsequently lowering the risk of diseases,» concludes the researcher.
FUENTE
